Discovery of (phenylureido)piperidinyl benzamides as prospective inhibitors of bacterial autolysin E from Staphylococcus aureus
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چکیده
منابع مشابه
Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2.
The identification and development of a novel series of small molecule Enhancer of Zeste Homologue 2 (EZH2) inhibitors is described. A concise and modular synthesis enabled the rapid development of structure-activity relationships, which led to the identification of 44 as a potent, SAM-competitive inhibitor of EZH2 that dose-dependently decreased global H3K27me3 in KARPAS-422 lymphoma cells.
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The rapid spread of antibiotic-resistance among pathogenic bacteria poses a serious risk for public health. The search for novel therapeutic strategies and antimicrobial compounds is needed to ameliorate this menace. The bifunctional metalloenzyme CapF is an antibacterial target produced by certain pathogenic bacteria essential in the biosynthetic route of capsular polysaccharide, a mucous laye...
متن کاملAn autolysin ring associated with cell separation of Staphylococcus aureus.
atl is a newly discovered autolysin gene in Staphylococcus aureus. The gene product, ATL, is a unique, bifunctional protein that has an amidase domain and a glucosaminidase domain. It undergoes proteolytic processing to generate two extracellular peptidoglycan hydrolases, a 59-kDa endo-beta-N-acetylglucosaminidase and a 62-kDa N-acetylmuramyl-L-alanine amidase. It has been suggested that these ...
متن کاملEvaluation of humoral and cellular immunity of recombinant autolysin protein Staphylococcus aureus in mouse model
Background: Staphylococcal aureus is a gram positive cocci and opportunistic pathogen. Due to the spread of this bacterium to antibiotics resistance, one of the most important ways of prevention is the use of vaccines. In this respect, autolysin protein as one of the adhesion molecule of bacteria plays an important role for binding bacteria to the host cells and cell division. Herein, the role ...
متن کاملBacterial Contamination and Antibiotic Resistance of Staphylococcus Aureus Isolated from Automated Teller Machine
Abstract Background and Objective: Automated Teller Machine (ATMs) is likely to be contaminated with various microorganisms specially pathogen germs. This may be due to their exposure to dust and their vast dermal contact with multiple users. This study investigated the bacterial contamination on the keyboard of ATMs and drug resistance of the bacteria isolated from them. Material and M...
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ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition and Medicinal Chemistry
سال: 2018
ISSN: 1475-6366,1475-6374
DOI: 10.1080/14756366.2018.1493474